I am taking Akurit-2 & Pyridoxine. My regime will be completed by the end of next week at Day 90.
I experienced mild nausea during the first few days on the meds. It reminds me of the bad morning sickness I had in my 2nd pregnancy. My urine did turn a hue of red and orange in the immediate 2-3 hours after swallowing the pills. Initially, I had thought that it would take me a few days to develop that sign. I also had horrible flu-like symptoms which is unpleasant to have during this pandemic. Coincidentally we had staff screening at the clinic that same week using the RTK-Antigen. I tested NEGATIVE for Covid-19.
I noticed I had nightmares too in the first week. I had horrible dreams of Covid-19, dengue fever and other weird disease management. Not sure if it is an after-effect of stress at work or the meds. I did not have insomnia. Instead, I have terrible somnolence. It was as bad as taking Actifed for my occasional runny nose. I did not experience major peripheral neuropathy (so far). My liver function was monitored at 2 weeks and 2 months after starting the treatment. So far, it has been normal.
The paramedic in-charge of my regime allowed me to bring home 2 weeks supply of the medicine. I don’t have to take it at the same time everyday but it would be helpful to stick to one. Akurit-2 is best taken on an empty stomach for better absorption unlike pyridoxine where you can take it at anytime you want. Obviously, I take them together.
I have had people asking me if this would KILL ALL THE TB BACTERIA in my body.
The thing is, Medicine is never 100% guaranteed. There is always a small percentage of patients that will still have active TB one day. On my part, I am doing this for myself, my family and the people around me. I also took my Pfizer vaccine shot whilst on the treatment. I did not experience any major side effects from being on the regime and taking the vaccine. Yes, I did have malaise and a mild fever 24 hours after the 2nd dose of Pfizer but that’s it. Now I feel fine.
Cost of treatment for latent TB
As a Malaysian citizen, I only need to pay RM1 for registration and for every visits to see my attending doctor. I have had two visits. That means on top of the initial RM1, I am paying another RM2. My blood works are FREE. My consultation fee is FREE. My medicine is FREE.
It started off with a new colleague at my workplace being diagnosed with active pulmonary tuberculosis (PTB). Which consequently led to all her close contacts being screened for it as well. It was normal practice for every new staff to have themselves checked for PTB, a similar process I went through about 2 years ago, with a negative result.
The screening process involved going through the symptoms and sending a sputum sample (if present), doing a chest XRAY and a Mantoux test.
I had no symptoms, my chest XRAY was normal BUT my Mantoux test was glaringly positive this time around. Even I was shocked because I never had this response during my previous Mantoux tests done in my previous workplace and upon entering this new premise.
Since we had a blood test called IGRA to further confirm the diagnosis, I took the test. Lo and behold, it was POSITIVE. There is no denying of the TB organism in my body- only that it is asleep. It does not have the capacity to give me an infection that manifests the classic symptoms of TB. Now it is my choice of whether I would want to be treated for it or otherwise. Of course in medicine there is no 100% guarantee that it will wipe away the TB and prevent reactivation but it is worth trying.
I first had to do a baseline blood test for my liver function. I ended up screening for my cholesterol and diabetes all. Since my blood works are fine, my doc discussed with me of a few treatment regimes. There are monotherapy treatments which can take up to 6 months and a combination therapy for 3 months. I missed the trial period for a study using a drug called Rifapentine which is to be taken weekly for 6 weeks. Therefore, my choices are limited. My attending Dr and I agreed upon the combination therapy.
My regime is Akurit-2 (rifampicin + isoniazide) 4 tabs daily & pyridoxine 10mg once daily for 90 days. If my weight was less than 55kg, I would have been given 3 tabs instead. It is weight dependent. ha ha ha.
Expected major reactions would be a red-orange hue in my body secretions (tears, urine, sweat) and a degree of peripheral neuropathy. Perhaps also bodily ache and gastrointestinal symptoms. My liver functions will be monitored on intervals and I will personally look out for a tinge of jaundice on myself.